Add the supplements, medications, and compounds in your longevity stack. This tool checks for known interactions between them — with severity grades, mechanisms, and cited research.
The longevity community routinely combines multiple supplements, off-label medications, and experimental compounds in pursuit of extended healthspan. Stacks commonly include NMN or NR for NAD+ support, rapamycin for mTOR inhibition, metformin or berberine for AMPK activation, omega-3 fatty acids for inflammation, and a statin for cardiovascular protection. Each compound may be well-studied individually, but the interaction profile of a complex stack is rarely assessed as a whole.
Existing drug interaction checkers — such as those from WebMD, Drugs.com, or Medscape — are designed for pharmaceutical medications and often lack data on longevity-specific supplements like NMN, NR, pterostilbene, fisetin, or spermidine. This tool fills that gap by focusing specifically on the compounds used in evidence-based longevity protocols.
The Longevity Stack Interaction Checker evaluates pairwise interactions between all compounds in your stack. For each interaction found, it provides a severity grade (high, moderate, low, or beneficial synergy), an explanation of the biological mechanism involved, a recommended action, and references to relevant peer-reviewed research. Interactions are categorized by their clinical significance — from potentially dangerous combinations that require medical supervision to synergistic pairings that may enhance effectiveness.
Some of the most frequently searched interactions in the longevity space include berberine and metformin (both activate AMPK and may cause additive hypoglycemia), rapamycin and metformin (opposing effects on certain metabolic pathways), NMN and exercise timing (potential interference with exercise adaptations), and omega-3 with blood thinners (additive anticoagulant effects). This tool covers these and dozens of additional pairwise interactions drawn from published pharmacokinetic and pharmacodynamic research.
All interaction data in this tool is derived from peer-reviewed research, including randomized controlled trials, pharmacokinetic studies, systematic reviews, and established pharmacological databases. Where human data is limited — as is the case for some newer longevity compounds — the tool notes this explicitly and indicates when evidence comes from preclinical models. Citations are provided for each interaction to allow independent verification.